Since the 2017–18 season the Sabres and Senators have met 30 times in the regular season, with the Sabres holding a 16–14 edge in the series.
Most recently the Senators won 4–1 on April 2, 2026.
Right now the Sabres are 2–1–0 and the Senators are 2–1–0, with the Senators at 2 days since a win against the Sabres' 1.
| Season | Wins |
|---|---|
| 2025–26 | Sabres 2, Senators 1 |
| 2024–25 | Sabres 4, Senators 0 |
| 2023–24 | Sabres 2, Senators 2 |
| 2022–23 | Sabres 2, Senators 2 |
| 2021–22 | Sabres 1, Senators 2 |
| 2019–20 | Sabres 1, Senators 3 |
| 2018–19 | Sabres 2, Senators 2 |
| 2017–18 | Sabres 2, Senators 2 |
| Date | Host | Winner | Score |
|---|---|---|---|
| April 2, 2026 | Senators home | Senators | 4–1 |
| December 23, 2025 | Senators home | Sabres | 3–2 |
| October 15, 2025 | Sabres home | Sabres | 8–4 |
| April 1, 2025 | Senators home | Sabres | 5–2 |
| March 25, 2025 | Sabres home | Sabres | 3–2 |
| January 9, 2025 | Senators home | Sabres | 4–0 |
| November 5, 2024 | Sabres home | Sabres | 5–1 |
| March 27, 2024 | Sabres home | Senators | 6–2 |
| January 11, 2024 | Sabres home | Sabres | 5–3 |
| December 31, 2023 | Senators home | Senators | 5–1 |
| October 24, 2023 | Senators home | Sabres | 6–4 |
| April 13, 2023 | Sabres home | Sabres | 4–3 |
| January 1, 2023 | Senators home | Senators | 3–1 |
| November 16, 2022 | Senators home | Senators | 4–1 |
| October 13, 2022 | Sabres home | Sabres | 4–1 |
Full schedules and drought counters: Buffalo Sabres and Ottawa Senators.
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